"With a name like Gohberg–Goldberg–Kaashoek, it has got to be good. But let me count the ways. If you are interested in learning the basic theories of Hilbert and Banach spaces together with the well-known operators that act on them, this book is for you. It is intended for advanced undergraduate and beginning graduate students in...
This is the second volume in a series of innovative proceedings entirely devoted to the connections between mathematics and computer science. Here mathematics and computer science are directly confronted and joined to tackle intricate problems in computer science with deep and innovative mathematical approaches.
Sodium channels confer excitability on neurons in nociceptive pathways and exhibit neuronal tissue specific and injury regulated expression. This volume provides recent insights into the control of expression, functioning and membrane trafficking of nervous system sodium channels and reviews why sodium channel sub-types are potentially...
Despite tremendous advances in the understanding of the sensory nervous system which have accompanied the recent explosive growth of the neurosciences, rema- ably few innovative medicines directed towards pain and inflammation are ava- able. Indeed, many patients are still prescribed analgesic and anti-inflammatory medications that were...
After three introductory chapters that deal with the general theme of obesity – now regarded as a chronic disease – this volume discusses the drugs sibutramine and orlistat, which are approved for long-term use in the US and in much of the rest of the world. The three final chapters discuss future drug targets, like the central...
The NPY-family of peptides encompasses several groups of neurotransmitters and hormones, which exert diverse biological and pathological actions that bear on all major vital systems. The recognition of the role of NPY in stimulation of food intake has already resulted in discovery of potent and selective NPY receptor Y-5 antagonists which are...
This monograph examines the contribution of imaging modalities to the stages of drug discovery and development, from early target validation to their use in clinical development programs. Chapters are devoted to the description of the drug discovery process, to the various imaging modalities preclinically and clinically, to applications of...
Chemokines play an important role in recruiting inflammatory cells into tissues in response to infection and inflammation. They also play an important role in coordinating the movement of T-cells, B-cells and dentritic cells, necessary to generate an immune response (response to injury, allergens, antigens, invading microorganisms). They...
The firm of Denis Valode and Jean Pistre, which has been practicing for 25 years, entered upon a new phase of its career in 1992, when the architects — in cooperation with the landscape architect Kathryn Gustafson — received the Equerre d’argent prize of the journal Le Moniteur for the L’Oréal corporate headquarters...
An important aspect of multi agent systems are agent reasoning techniques for problem solving, either at the level of a single agent or at the level of distributed collaboration amongst multiple agents.
Constraint Satisfaction Problems (CSP) prove to be a generic framework which can be applied for modeling and solving a wide range...
From the emergence of clinical sleep medicine marked by the establishment of the harbinger Stanford Sleep Disorders Clinic in the mid 1970s, offspring sleep dis- ders clinics and centers have grown exponentially with the recognition of the unmet diagnostic and treatment needs of the reservoir of patients suffering from sy- toms of what are...
In February 2004, at the Universitat Polit`ecnica de Catalunya, we presented a
45-hour Advanced Course on Contemporary Cryptology, organised by the Centre
de Recerca Matem`atica. This volume is an expanded and unified version of the
material presented in the lectures and the background material that we distributed
among the...
