Cystic fibrosis used to be thought of as a respiratory and digestive disease, with a uniformly and rapidly fatal outcome. The spectrum of the disease has broadened into the mild atypical case, presenting in middle age, with the potential for complications in virtually every system of the body. In the past few years there has been an explosion...
In 1999, my colleagues and I performed a study in 7
hospitals in different regions throughout Spain where 305
patients were questioned about their use of antimigraine
medications [1] . The patients reported previous use of the
following acute agents: analgesics (99%), nonsteroidal antiinfl
ammatory drugs (NSAIDs, 69%),...
Herpes zoster is a serious neurocutaneous disease which has been underestimated
in terms of its burden, particularly in the elderly population. The
overall incidence of herpes zoster in Europe is about 3 per 1,000 people and
more than 10 per 1,000 people per year aged more than 80 years. Due to the
growing life expectancy of the...
Cancer and other genetic human diseases are caused by a variety of mutations, ranging from subtle sequence changes to larger genomic rearrangements and alterations in chromosome number (aneuploidy). With contributions by reputed experts, this book aims to update the knowledge on the multiple mechanisms of genomic instability leading to human...
Over the last 15 years, apoptosis has become a dominant focus of medical research in the field of immunology. This publication discusses the three major areas of apoptosis research: extrinsic death receptor pathways, intrinsic cell death pathways and the mechanisms responsible for apoptotic cell clearance. Each section delineates the proteins...
The last two decades have shown that the local microenvironment plays a pivotal role in cancer progression. Cancer is not the result of mutation events in single cells, but of a complex interplay of tumor cells, inflammatory cells, stem cells, growth factors, cytokines, chemokines and DNA-damaging agents. This book provides an up-to-date...
In this volume, world-renowned specialists review the latest scientific information and recommendations for protein and energy requirements of infants and children. New data obtained with the latest techniques show significantly lower requirements for both energy and protein than previously thought. This will have far-reaching implications...
Over the next decade, the global number of people with diabetes and at risk of diabetes and cardiovascular disease is expected to grow by 25%, largely driven by the rising prevalence of obesity and inactivity. The problem is especially serious in Asia, where the WHO predicts that in less than a decade, 60% of the worldwide population with...
Dental Erosion: A challenge for the 21st century! This monograph offers a
guide towards better oral health in the future. Erosive tooth wear is a multifactorial
condition of growing concern to the clinician and the subject of extensive
research – a view supported by the literature and impressions from many international...
The International Stereotactic Radiosurgery Society represents a community
of colleagues across the world. The 7th meeting of the society was held in
Brussels, Belgium under the leadership of meeting chairman Dr. Marc Levivier
and scientific program chairman, Dr. Jean Regis. Professor Jacques Brotchi
served as the Honorary...
Otosclerosis is a disorder causing a hardening of the middle ear bones which leads to a progressive hearing loss. Internationally renowned experts met in Saas Fee (Switzerland) in 2004 to discuss otosclerosis and stapes surgery, and they have subsequently been invited by the editor to present their findings in this publication. From basic to...
In recent years the development of new technologies has permitted the production of 'functional' or 'smart' textiles. These fabrics are capable of sensing changes in environmental conditions or body functions and are adequately responding to them. They are able to absorb substances from the skin or to release therapeutic or...
