"In a clear, engaging style, Dr. Walters tells the tale of each disease like a detective story. He allows each mystery to unfold as it did in reality, often slowly, through the lives of the plants and animals involved, the first human victims, the government officials who tried to respond, and the scientists who ultimately explained what...

The IGF system pervades the fields of development, linear and cellular growth and metabolism. Not only is the functional integrity of the IGF system crucial for normal linear growth and metabolism, it is also of fundamental importance for normal fetal development. This book consists of a compilation of chapters based on presentations at a...

Considerable evidence indicates that the U.S. is falling behind when it comes to innovation. In part, this shift stems from the globalization of research and the advancement of other nations. But, it also arises from a widespread failure to adapt to the competitive environment generated by the evolution of science and technology.
The...

This volume gives a comprehensive overview on the most relevant leukocyte and endothelial adhesion molecules. The chapters are written by leaders in the field and focus on the biology, structure, function, and regulation of adhesion molecules. Currently approved adhesion molecule-based therapies are reviewed and an outlook for future...

One of the most fruitful areas of research, as judged by the very large numbers of new cancer genes identified, has been the molecular analysis of recurrent chromosomal translocations. The original concept that gave rise to this book was that key scientists involved in the original isolation of the genes involved in each recurrent solid tumor...

Cytokines and cytokine receptors remain an area of great interest for the development of targeted therapies for cutaneous inflammatory diseases. Anti-TNF therapeutics have proven to be effective in the treatment of psoriasis, and clinical investigations have now begun for other cytokine-directed therapies, such as those targeting IFN-g,...

Based on evidence-based medicine guidelines, the first part of the book describes...

Sodium channels confer excitability on neurons in nociceptive pathways and exhibit neuronal tissue specific and injury regulated expression. This volume provides recent insights into the control of expression, functioning and membrane trafficking of nervous system sodium channels and reviews why sodium channel sub-types are potentially...

The catecholamine dopamine (DA) plays a key role in the physiology of most vertebrate and invertebrate organisms. In addition to its role as a transmitter in the nervous system, it has a role in development. The relatively few DA neurons in the mammalian brain have important roles in many neural functions including fine motor integration,...

If you thought negotiating deals and agreements is tough in today's business environment, then you should try doing so in prehistoric times! This book follows our two cavemen characters, Tork and Grunt, in their quest to ensure the survival of their tribe. Through the experiences of our two cavemen, you will learn everything you need to...

The study of how a neurological disorder can change the artistic activity and behavior of creative people is a largely unexplored field. This publication looks closer at famous painters, writers, composers and philosophers of the 18th to the 20th centuries who...