This volume presents up-to-date, comprehensive and high quality reviews of the psychopharmacological evidence-base for each of the major psychiatric disorders, written by expert psychopharmacologists from around the world. Building on the success of the first edition, the volume summarizes the wealth of new developments in the field and sets...

This book gives a comprehensive treatment of the singularities that appear in the minimal model program and in the moduli problem for varieties. The study of these singularities and the development of Mori's program have been deeply intertwined. Early work on minimal models relied on detailed study of terminal and canonical singularities...

This text provides a complete introduction to the theory of variational inequalities with emphasis on contact mechanics. It covers existence, uniqueness and convergence results for variational inequalities, including the modelling and variational analysis of specific frictional contact problems with elastic, viscoelastic and viscoplastic...

The famous Circuit Double Cover conjecture (and its numerous variants) is considered one of the major open problems in graph theory owing to its close relationship with topological graph theory, integer flow theory, graph coloring and the structure of snarks. It is easy to state: every 2-connected graph has a family of circuits covering every...

The 400-year-old Kepler conjecture asserts that no packing of congruent balls in three dimensions can have a density exceeding the familiar pyramid-shaped cannonball arrangement. In this book, a new proof of the conjecture is presented that makes it accessible for the first time to a broad mathematical audience. The book also presents...

Merciful Judgments in Contemporary Society: Legal Problems/Legal Possibilities explores the tension between law's need for and dependence on merciful judgments and suspicions that regularly accompany them. Rather than focusing primarily on definitional questions or the longstanding debate about the moral worth and importance of mercy,...

Fully revised throughout, the second edition of Manual of Stem Cell and Bone Marrow Transplantation is based on the in-house handbook used at the world-renowned Dana-Farber Cancer Institute. It is a practical pocket manual for all members of the stem cell and bone marrow transplant team. Written by experts at Dana-Farber, the contents are...

Providing an up-to-date overview of the most popular global optimization methods used in interpreting geophysical observations, this new edition includes a detailed description of the theoretical development underlying each method and a thorough explanation of the design, implementation and limitations of algorithms. New and expanded chapters...

Chronicling the emergence of an international society in the 1920s, Daniel Gorman describes how the shock of the First World War gave rise to a broad array of overlapping initiatives in international cooperation. Though national rivalries continued to plague world politics, ordinary citizens and state officials found common causes in...

In this new edition of the best-selling Introduction to Buddhism, Peter Harvey provides a comprehensive introduction to the development of the Buddhist tradition in both Asia and the West. Extensively revised and fully updated, this new edition draws on recent scholarship in the field, exploring the tensions and continuities between the...

Modeling atmospheric processes in order to forecast the weather or future climate change is an extremely complex and computationally intensive undertaking. One of the main difficulties is that there are a huge number of factors that need to be taken into account, some of which are still poorly understood. The Factor Separation (FS) method is...

This book examines one of the thorniest problems of ancient American archaeology: the origins and domestication of maize. Using a variety of scientific techniques, Duccio Bonavia explores the development of maize, its adaptation to varying climates, and its fundamental role in ancient American cultures. An appendix (by Alexander Grobman)...