Obesity and diabetes develop as a complex result of genetic, metabolic and environmental factors and are characterized by increased lipogenesis and lipid accumulation in many tissues. Stearoyl-CoA desaturase (SCD) genes are a critical regulator of lipogenesis and catalyzes the synthesis of monounsaturated fatty acids (MUFA), mainly oleoyl-...

Biology and history are often viewed as closely related disciplines, with biology informed by history, especially in its task of charting our evolutionary past. Maximizing the opportunities for cross-fertilization in these two fields requires an accurate reckoning of their commonalities and differences―precisely what this volume sets out...

Elliptically Contoured Models in Statistics and Portfolio Theory fully revises the first detailed introduction to the theory of matrix variate elliptically contoured distributions. There are two additional chapters, and all the original chapters of this classic text have been updated. Resources in this book will be valuable for researchers,...

The main purpose of the present volume is to advance our understanding of the notions of knowledge and context, the connections between them and the ways in which they can be modeled, in particular formalized – a question of prime importance and utmost relevance to such diverse disciplines as philosophy, linguistics, computer science...

This is a basic book on evidence-based medicine (EBM). It starts with an introduction to the topic. It outlines the relationship between EBM and research and quality of care. Then It goes on to cover the most commonly used modules of EBM, i.e. therapy, diagnosis, prognosis and meta-analysis. Each module starts with an introduction to...

In dem Buch werden Data-Warehouse-Systeme als einheitliche, zentrale, vollständige, historisierte und analytische IT-Plattform untersucht und ihre Rolle für die Datenanalyse und für Entscheidungsfindungsprozesse dargestellt. Dabei behandelt der Autor die einzelnen Komponenten, die für den Aufbau, die Architektur und den...

Polymer science is now an active and thriving community of scientists, engineers and technologists, but there was a time, not so long ago, when there was no such community. The prehistory of polymer science helps to provide key insights into current issues and historical problems. The story will be divided into an ancient period ( from Greek...

Today’s financial system is considerably more complex than in years past, as new financial instruments have been introduced that are not well understood even by the people and institutions that invest in them. Numerous high-risk opportunities are available, and the number of people who unwittingly wander into such ventures seems to grow...

In this volume, the authors apply insights from a variety of perspectives to explore the alignment among strategy, organization design, process and human resource management, and e-business practices on developing successful social networking programs―with particular regard to applying such initiatives against the backdrop of the global...

This book collects several contributions, written both by statisticians and medical doctors, which focus on the identification of new diagnostic, therapeutic and organizational strategies in order to improve the occurrence of clinical outcomes for Acute Coronary Syndromes (ACS) patients. The work is structured in two different...

The familiar image of the disabled tends to emphasize their limitations and reduced quality of life. However, many people with cognitive, motor, and other difficulties also have the capacity to enhance their social interactions, leisure pursuits and daily activities with the aid of assistive...

​By investigating the properties of the natural state, this book presents an analysis of input-output systems with regard to the mathematical concept of state. The state of a system condenses the effects of past inputs to the system in a useful manner. This monograph emphasizes two main properties of the natural state; the...