This book describes some of the most exciting developments for the discovery of new drugs, such as Fragment-based methods. It contains the latest developments in technologies that can be used to obtain the 3-D structures. This book includes experimental approaches using X-ray crystallography and NMR for Fragment-based screening as well as...
The aim of this book is to give an in-depth assessment of our current understanding of the Biology of the main fungal pathogens and how they interact with the host’s immune response. Each chapter focuses on a specific fungal pathogen or group of pathogens, and examines their biology and the factors that allow the fungus to colonize and...
"This water" he told me, "runs out to the eastern region, and flows into the Arabah; and when it comes into the sea, into the sea of foul waters [i. e. , the Dead Sea], the water will become wholesome. Every living creature that swarms will be able to live wherever this stream goes; the fish will be very abundant once these...
At last – a second edition of this hugely important text that reflects the progress and experience gained in the last decade and aims at providing background and training material for a new generation of risk assessors. The authors offer an introduction to risk assessment of chemicals as well as basic background information on sources,...
This book describes molecular processes whose deregulation is important in the formation of tumors. The material is developed from basic cell signaling pathways to their roles in the clinical manifestation of specific cancers. Topics covered include molecular events intrinsic to tumor cells (leading to growth deregulation, extended lifespan,...
This is a book for people who love mechanics of composite materials and ? MATLAB . We will use the popular computer package MATLAB as a matrix calculator for doing the numerical calculations needed in mechanics of c- posite materials. In particular, the steps of the mechanical calculations will be emphasized in this book. The reader will not...
This title introduces state-of-the-art design principles for SOI circuit design, and is primarily concerned with circuit-related issues. It considers SOI material in terms of implementation that is promising or has been used elsewhere in circuit development, with historical perspective where appropriate.
Research in Bayesian analysis and statistical decision theory is rapidly expanding and diversifying, making it increasingly more difficult for any single researcher to stay up to date on all current research frontiers. This book provides a review of current research challenges and opportunities. While the book can not exhaustively cover all...
Many engineering, operations, and scientific applications include a mixture of discrete and continuous decision variables and nonlinear relationships involving the decision variables that have a pronounced effect on the set of feasible and optimal solutions. Mixed-integer nonlinear programming (MINLP) problems combine the numerical...
This uniquely convenient reference offers important focus on motor dysfunction, hundreds of illustrations and easy-scan charts, patient-teaching points, and expert advice for unusual clinical situations, and women's health. Contents include general assessment, signs and symptoms, outcome measurement, diagnostic tests, rhythm strip...
"Take away my knee pain and give me better motion". This is what the arthritic patient expects from a Total Knee Arthroplasty (TKA). By virtue of standardization of the TKA procedure, surgeons can nowadays solve the pain issue for the majority of the patients.
Restoration of function is a goal of a different order and...
Lebenslaufanalyse und Biografieforschung haben sich in den letzten Jahrzehnten zu einem zentralen Instrument der Untersuchung von Individualisierung in dynamischen Gesellschaften entwickelt. Der Band erläutert die wichtigsten Theorien auf diesem Gebiet (Generation, Alter, Biografie, Institutionalisierung). Die qualitativen und...
