Douglas P. Beall, MD, summarizes the early experiences of established clinicians to create a compendium of everything you need to know during your formative years in radiology. Written for radiology residents and fellows and newly minted radiologists, the Radiology Sourcebook provides vital professional information and sound guidance on such...

Leading urologists and expert specialists review and summarize for family practitioners the latest thinking about how best to evaluate, diagnose, and treat all the most commonly encountered urological conditions. Topics discussed range from urinary tract infections in children and adults to the evaluation and treatment of hematuria, kidney...

An interdisciplinary panel of pioneers and opinion leaders review the basic, preclinical, clinical, and developmental pathways to new treatment strategies, such as therapeutic angiogenesis and myogenesis. The authors take advantage of new biological understanding, novel therapeutic targets, multiple available and well-studied therapeutic...

Bruce R. Smoller, md, concisely reviews for practitioners and students alike the science of immunopathology, its many basic laboratory tools, and their multiple diagnostic uses in actual clinical case studies. The author presents in an easily digestible form a dictionary of antibody probes, summarizing for each antibody the targeted antigen...

A collection of cutting-edge methods for investigating G protein signaling from a variety of perspectives ranging from in vitro biochemistry to whole animal studies. Among the readily reproducible techniques presented are those for the purification of G proteins and effectors enzymes, assays of these purified G proteins and effector enzymes,...

In Heme, Chlorophyll, and Bilins: Methods and Protocols, an interdisciplinary panel of hands-on investigators describe in detail how to work successfully with chlorophyll, heme, and bilins in biological, medical, chemical, and biochemical research. Each method is presented by a researcher who actually uses it on a daily basis and includes...

12 The average human body has in the order of 10 circulating platelets. They are crucial for hemostasis, and yet excessive platelet activation is a major cause of m- bidity and mortality in western societies. It is therefore not surprising that platelets have become one of the most extensively investigated biological cell types. We are,...

Expert laboratorians update the classic bioconjugation methods and introduce valuable new techniques that go beyond pure biomedical applications to include elements from advanced organic synthesis, molecular biology, and materials science. These readily reproducible methods cover the preparation of protein conjugates using covalent and...

Despite significant advances in cancer treatment and measures of neoplastic progression, drug effect (or early detection, overall cancer incidence has increased, pharmacodynamic markers), and markers that measure cancer-associated morbidity is considerable, and overall prognosis as well as predict responses to specific therapy. cancer...

A comprehensive reference survey on the identification and development of promising cancer chemopreventive agents that will help stimulate further novel research and new approvable drugs. For each agent, the authors review the relevant mechanisms of action, the criteria for populations benefiting from intervention, the safety and...

Cells respond to environmental cues through a complex and dynamic network of signaling pathways that normally maintain a critical balance between cellular proliferation, differentiation, senescence, and death. One current research challenge is to identify those aberrations in signal transd- tion that directly contribute to a loss of this...

Recognized experts comprehensively review the clinical, surgical, radiological, and scientific aspects of atherosclerotic peripheral arterial disease (PAD), including endovascular, gene, and drug therapies. In their far-ranging discussions, the authors examine in depth the risk factors and antiplatelet therapies for PAD patients at high risk...